Consult with Dr. Nancy Mullan 3/7/13 phone
Some folks up on Facebook asked me to post these notes. They will mean nothing to you unless you are a methylation genetics geek. If so, enjoy!
To do:
-
Look at CYP1B1. This
points to detoxification of phytoestrogens.
Nancy’s suspicion is that R_M’s issue has to do with this. [figured out
that R_M has +/+ for CYP1B1 R48G, other 2 are -/- EMAIL Dr. Mullan about this result]
-
Read article “GI balance and neurotransmitter formation” on
Dr. Mullan’s blog “ChronicDiseaseTalk.com”
-
Read up on Dr. Amy’s forum.
Dr. Mullan says the approach has changed a lot, is “much simpler now”,
doesn’t start with the long way on MTHFR (B12/folate) anymore.
-
Go to DirectLabs, price the first 4 tests. Ask Brie about running them too.
-
Look up prices for all the Yasko products Dr. Mullan
mentioned.
Advice:
-
Stay away from dairy – numerous problems, including estrogens
-
Figure out if there’s an issue with phytoestrogens – this is
Dr. Nancy’s suspicion, because of her age and timing coincidence with menarche.
-
Take cal-d-glucarate to detox estrogen
They do several tests when they check the gut – (Genova and
GI Effects?) look for aerobic and anaerobic, h.pylori – they spend a lot of
energy trying to figure out if there is h.pylori present – apparently very hard
to find, hides in deep crypts, etc.
CBS mutation – look for high taurine to see if this is
causing issues
Dr. Amy now does 9 tests.
Starts with first 4, all run on the same day:
- Hair analysis
- Urine toxic elements
- Urine essential elements
- Urine amino acids
- Genetics
- Tests for only 4 neurotransmitters: norepinephrine, tryptophan, serotonin, epinephrine
Fundamental changes to Yasko approach:
-
They don’t treat the “long” leg of methylation first anymore –
they start with the BH4 route now.
-
They use SAM-E instead of Methyl B12 these days but not sure
she would give R_M this, at least not to start.
-
They don’t use Yucca for CBS anymore – used to think high
ammonia was due to CBS, figured out it wasn’t.
General order of treatment:
- Gut
- Minerals
- RNA
- Phos-serine, choline, ethanol
- DHA neuromins
Order of specific supplementation:
- CBS RNA – To control “down the drain” effect of CBS (she says there is no other way)
- “BHMT MTHFR Support” – I think this is a product – Did she mean MTHFR RNA? R_M does not have any BHMT snips.
- A1298C Support formula – This is a product
- Digestive enzymes (optional)
- Gut support (probiotics, pathogen killing etc. I assume)
- Vita Organ - A product
- Leaky Gut RNA – A product
- Minerals - Zinc/lithium/mag – can get a serum lithium, sounds like they give this a lot, plus an ionic trace mineral supp.
- Phosphatidylserine, then phosphatidylcholine than phos-e______
- DHA Neuromins
CBS RNA $85.00
MTHFR RNA? $85
http://www.holisticheal.com/mthfr-3.html
A1298 Liver
Support $54.95
http://www.holisticheal.com/mthfr-a1298c-liver-support-bh4-function-2.html
Vita Organ $74.95
Leaky Gut RNA $85
http://www.holisticheal.com/leaky-gut.html
